Circulating markers of oxidative stress are associated with a muscle injury in patients with muscular dystrophy Duchenne

BackgroundA small number of studies have confirmed the presence oxidative damage in patients with Duchenne muscular dystrophy (DMD). Nevertheless, it is unknown if there a relationship circulating markers stress muscle injury.ObjectiveWe evaluated and anti-oxidant are associated DMD.MethodsThis cross-sectional study included 24 DMD classified ambulatory non-ambulatory. Markers (creatine kinase [CK]), (malondialdehyde [MDA], 8-isoprostane), function (Thiol mRNA NRF2 NF-κB) nitric oxide (NO) were quantified circulation.ResultsTotal NO, MDA, 8-isoprostane concentrations significantly (p < 0.05) higher, thiol concentration was lower non-ambulatory than patients. A significant correlation between injury (evaluated by Vignos scale) CK (r = −0.382), NO 0.444), MDA 0.503), 8-isoprostanes 0.435) −0.430) observed. Conclusion: These findings suggest that high low DMD. Total plasma increase, but marker decreases boys The this these could be considered as goods indicators longitudinal to evaluate during progression. Additionally, add new information about pathophysiology